HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 473857Generated: October 31, 2026
Hydrochloric Acid → 7-(Thiazol-5-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine
https://huagongshe.com/reaction/473857
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 7-(thiazol-5-yl)-2,3-dihydrobenzo[f][1,4]oxazepine-4(5H)-carboxylate | HCID 67513975 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-(Thiazol-5-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine | HCID 67513777 | — |
Reaction Steps
To tert-butyl 7-(thiazol-5-yl)-2,3-dihydrobenzo[f][1,4]oxazepine-4(5H)-carboxylate (41 mg, 0.12 mmol) in methanol (5.0 mL) added 4.0 M hydrogen chloride in dioxane (3.0 mL) and the mixture stirred at 25° C. for 20 minutes then concentrated to give 7-(thiazol-5-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637499B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-19354eccf416490299845b21beac5306 |
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| Source note | uspto-grants-2014_01 |
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