Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

Participants

Reaction Steps

To a solution of tert-butyl 3-cyano-3-methylazetidine-1-carboxylate (30.0 mg, 0.15 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (2 ml) and the solution stirred at room temperature for 1 hr. The reaction was concentrated and dried under vacuum to give a viscous oil which was used crude in subsequent chemistry.

Provenance & Evidence