Glyoxylic Acid → 4-(2-Ethoxy-naphthalene-1-yl)-6-iodo-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

HRID 47417Notes

Reaction equation

HRID 47417 reaction equation
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9]([OH:13])(=[O:12])[CH:10]=O.[CH2:14]([O:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]=1[CH:27]=[CH2:28])[CH3:15]>>[CH2:14]([O:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]=1[CH:27]1[C:7]2[C:5](=[CH:4][CH:3]=[C:2]([I:1])[CH:8]=2)[NH:6][CH:10]([C:9]([OH:13])=[O:12])[CH2:28]1)[CH3:15]

Participants

4

Procedure

Compound 73 was prepared from 4-iodoaniline, glyoxylic acid and 2-ethoxy-1-vinylnaphthalene by the automated process.

Sources & evidence

ORD record
ord-3ae91b3a01bf47ce849814325651b476
Source dataset
uspto-grants-2004_03
Patent number
US06699877B2

Reaction notes

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