Ethyl formate → HCID 46836675, compound

HRID 474220Notes

Reaction equation

HRID 474220 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]3[N:20]=[CH:19][C:18]([O:21][CH2:22][CH:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)=[CH:17][N:16]=3)[CH:10]=2)[N:6]=[C:5]([C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=2)[C:32]#[N:33])[CH:4]=[CH:3]1.[CH:37](OCC)=[O:38]>>[CH:37]([N:26]1[CH2:25][CH2:24][CH:23]([CH2:22][O:21][C:18]2[CH:17]=[N:16][C:15]([C:11]3[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=3)[CH2:8][N:7]3[C:2](=[O:1])[CH:3]=[CH:4][C:5]([C:29]4[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=4)[C:32]#[N:33])=[N:6]3)=[N:20][CH:19]=2)[CH2:28][CH2:27]1)=[O:38]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 46836198HCID 46836198, compound

Product 1

HCID 46836675HCID 46836675, compound

Procedure

239 mg (0.5 mmol) of 3-(6-oxo-1-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-1,6-dihydropyridazin-3-yl)benzonitrile are suspended in 10 ml of ethyl formate and refluxed for 8 h. The reaction mixture is evaporated and purified by means of column chromatography on silica gel.

Workup

  1. temperaturerefluxed for 8 h
  2. customThe reaction mixture is evaporated
  3. custompurified by means of column chromatography on silica gel

Sources & evidence

ORD record
ord-7c25c244da2e430f94f75aa8a615c88e
Source dataset
uspto-grants-2014_01
Patent number
US08637518B2

Reaction notes

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