HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-(4-(2-Cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Fluoro-4-nitrobenzonitrile | HCID 2759048 | — |
| Reactant | 2-(3,4-Dihydroxybutyl)isoindoline-1,3-dione | HCID 21592489 | — |
| Product | 2-(4-(2-Cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid | HCID 66665258 | — |
Reaction Steps
2-(3,4-dihydroxybutyl)isoindoline-1,3-dione was reacted as described in Intermediate Y(2) with sodium hydride and 2-fluoro-4-nitrobenzonitrile in THF to get 2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid which is used as-is in the next step. LC-MS (M+H)+=400.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637523B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-a21c3b254e9a4dbd835dc04487976639 |
| Source note | uspto-grants-2014_01 |