HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutoxy)-4-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(4-(2-Cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid | HCID 66665258 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutoxy)-4-nitrobenzonitrile | HCID 66668359 | — |
Reaction Steps
2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid was reacted as described in Intermediate Y(3) with hydrogen chloride in dioxane to get 2-(4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutoxy)-4-nitrobenzonitrile which is used as-is in the next step. LC-MS (M+Na)+=404.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637523B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-3112e49a3cea47b8b6a95b273459b160 |
| Source note | uspto-grants-2014_01 |