反应详情

2-(4-(2-cyano-5-nitrophenoxy)-3-hydroxybutylcarbamoyl)benzoic acid was reacted as described in Intermediate Y(3) with hydrogen chloride in dioxane to get 2-(4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutoxy)-4-nitrobenzonitrile which is used as-is in the next step. LC-MS (M+Na)+=404.1.