Sodium Hydroxide → HCID 178466839, compound

HRID 47430Notes

Reaction equation

HRID 47430 reaction equation
C[O:2][C:3](=[S:14])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([C:11](=[O:13])[CH3:12])[CH:5]=1.[OH-].[Na+]>O.CO>[C:11]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[CH3:10])[C:3]([OH:2])=[S:14])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 545143563-Acetyl-4-methylthiobenzoic acid methyl ester

Product 1

HCID 178466839HCID 178466839, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

3-acetyl4-methylthiobenzoic acid methyl ester (0.43 g) in water:methanol (1:3, 290 ml) containing sodium hydroxide (0.2 g) was stirred for 6 h. Methanol was removed at reduced pressure and the solution acidified with conc. hydrochloric acid to give 3-acetyl-4-methylthiobenzoic acid (0.32 g) after filtration. m/z (API+): 211 (MH+).

Workup

  1. customMethanol was removed at reduced pressure

Sources & evidence

ORD record
ord-1e9ebb6485c646609f456ce86dbd73b0
Source dataset
uspto-grants-2004_03
Patent number
US06699879B1

Reaction notes

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