Hydrochloric Acid → 8-Ethyl-2-methylquinoline-4-carboxylic acid

HRID 47436Notes

Reaction equation

HRID 47436 reaction equation
C([O:3][C:4]([C:6]1[C:15]2[C:10](=[C:11]([CH2:16][CH3:17])[CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([CH3:18])[CH:7]=1)=[O:5])C.Cl>>[CH2:16]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[N:9]=[C:8]([CH3:18])[CH:7]=[C:6]2[C:4]([OH:5])=[O:3])[CH3:17]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 544927358-Ethyl-2-methylquinoline-4-carboxylic Acid Ethyl Ester

Product 1

HCID 15315958-Ethyl-2-methylquinoline-4-carboxylic acidYield 107.5%

Procedure

8-Ethyl-2-methylquinoline-4-carboxylic acid ethyl ester (0.205 g) and 5N HCl combined and the solution boiled for 7 h. Solvent was removed at reduced pressure to give the title compound (0.195 g) as a yellow solid. m/z (API+): 216 (MH+), 214 (API−) 214(M-H).

Workup

  1. customSolvent was removed at reduced pressure

Sources & evidence

ORD record
ord-c7903352670b44bdb4f7dc4e9dea4401
Source dataset
uspto-grants-2004_03
Patent number
US06699879B1

Reaction notes

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