反应详情

A solution of 3-o-tolyl-isoxazole-4-carboxylic acid ethyl ester (1.32 g, 5.71 mmol, 1.0 equiv), 6M HCl aqueous solution (40 mL) and acetic acid (24 mL) was heated to reflux for 5 hours. After cooling, the mixture was partitioned between water and ethyl acetate and separated. The organic phase was sequentially washed with water and saturated aqueous sodium chloride solution. The collected organic was then dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to give 930 mg (80%) of crude 3-o-tolyl-isoxazole-4-carboxylic acid which was used without purification.

1. temperatureto reflux for 5 hours
2. temperatureAfter cooling
3. customthe mixture was partitioned between water and ethyl acetate
4. customseparated
5. washThe organic phase was sequentially washed with water and saturated aqueous sodium chloride solution
6. dry with materialThe collected organic was then dried over anhydrous sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated under vacuum