反应详情

2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid (2.5 g), (DE 2058295) in methanol (75 ml) containing conc. sulfuric acid (3 drops) was boiled for 16 h. Solvent was removed at reduced pressure, the residue dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The organic phase was dried (Na2SO4) and solvent removed at reduced pressure to give 2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester (2.50 g). m/z (API+): 304 (MH+).

1. customSolvent was removed at reduced pressure
2. dissolutionthe residue dissolved in ethyl acetate
3. washwashed with aqueous sodium hydrogen carbonate
4. dry with materialThe organic phase was dried (Na2SO4) and solvent
5. customremoved at reduced pressure