HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(4-methoxyphenoxy)-5-nitrobenzoic acid | HCID 2800866 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Product | 2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester | HCID 54075534 | — |
Reaction Steps
2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid (2.5 g), (DE 2058295) in methanol (75 ml) containing conc. sulfuric acid (3 drops) was boiled for 16 h. Solvent was removed at reduced pressure, the residue dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The organic phase was dried (Na2SO4) and solvent removed at reduced pressure to give 2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester (2.50 g). m/z (API+): 304 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699879B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-fcd65e698cba4ce88f7661c0861eb09c |
| Source note | uspto-grants-2004_03 |