Hydrochloric Acid → HCID 178511154, compound

Participants

Reaction Steps

1.5 g (0.3.1 mmol) (1-{3-[(5-Cyclopropyl-2H-pyrazole-3-carbonyl)-amino]-phenyl}-3-hydroxy-propyl)-carbamic acid tert-butyl ester were dissolved in 40 ml dioxane and 15 ml 4 N HCl in dioxane were added. The mixture was stirred overnight, filtered and washed with dioxane. To this residue, 0.1 N NaOH and ethyl acetate was added, the aqueus phase was washed with ethyl acetate twice, the organic layer was dried over Na2SO4 and evaporated to dryness.

Provenance & Evidence