Hydrochloric Acid → HCID 178511154, compound

HRID 474447Notes

Reaction equation

HRID 474447 reaction equation
C(OC(=O)[NH:7][CH:8]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19]([C:21]2[NH:22][N:23]=[C:24]([CH:26]3[CH2:28][CH2:27]3)[CH:25]=2)=[O:20])[CH:13]=1)[CH2:9][CH2:10][OH:11])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH:8]([C:12]1[CH:13]=[C:14]([NH:18][C:19]([C:21]2[NH:22][N:23]=[C:24]([CH:26]3[CH2:28][CH2:27]3)[CH:25]=2)=[O:20])[CH:15]=[CH:16][CH:17]=1)[CH2:9][CH2:10][OH:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453531HCID 178453531, compound

Product 1

HCID 178511154HCID 178511154, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.5 g (0.3.1 mmol) (1-{3-[(5-Cyclopropyl-2H-pyrazole-3-carbonyl)-amino]-phenyl}-3-hydroxy-propyl)-carbamic acid tert-butyl ester were dissolved in 40 ml dioxane and 15 ml 4 N HCl in dioxane were added. The mixture was stirred overnight, filtered and washed with dioxane. To this residue, 0.1 N NaOH and ethyl acetate was added, the aqueus phase was washed with ethyl acetate twice, the organic layer was dried over Na2SO4 and evaporated to dryness.

Workup

  1. filtrationfiltered
  2. washwashed with dioxane
  3. additionTo this residue, 0.1 N NaOH and ethyl acetate was added
  4. washthe aqueus phase was washed with ethyl acetate twice
  5. dry with materialthe organic layer was dried over Na2SO4
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-a6fefaf0007e416ca9070246e2eb4dd8
Source dataset
uspto-grants-2014_01
Patent number
US08637532B2

Reaction notes

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