1-Chloro-7-methylisoquinoline → 4-[3-(7-Methyl-isoquinolin-1-ylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

HRID 474462Notes

Reaction equation

HRID 474462 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Cl[C:25]1[C:34]2[C:29](=[CH:30][CH:31]=[C:32]([CH3:35])[CH:33]=2)[CH:28]=[CH:27][N:26]=1>>[CH3:35][C:32]1[CH:33]=[C:34]2[C:29]([CH:28]=[CH:27][N:26]=[C:25]2[NH:2][C:3]2[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=2)[CH2:6][NH:7][C:8]2[C:17]3[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][N:9]=2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 222501861-Chloro-7-methylisoquinolineHCID 667633584-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride

Product 1

HCID 667626484-[3-(7-Methyl-isoquinolin-1-ylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

Procedure

The title compound was prepared according to Example 684 starting 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 1-Chloro-7-methyl-isoquinoline at 120° C.:

Sources & evidence

ORD record
ord-b54f85f0e8284da99f67ca788ec8647d
Source dataset
uspto-grants-2014_01
Patent number
US08637532B2

Reaction notes

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