Hydrochloric Acid → HCID 66763352, compound

HRID 474469Notes

Reaction equation

HRID 474469 reaction equation
C(O[C:6](=O)[N:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](=[O:38])[NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][NH:24][C:25]3[C:34]4[C:29](=[C:30]([C:35](=[O:37])[NH2:36])[CH:31]=[CH:32][CH:33]=4)[N:28]=[CH:27][N:26]=3)[CH:18]=2)[CH:10]=1)C)(C)(C)C.Cl>O1CCOCC1>[CH3:6][NH:7][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[C:15]([NH:16][C:17]1[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=1)[CH2:23][NH:24][C:25]1[C:34]2[C:29](=[C:30]([C:35]([NH2:36])=[O:37])[CH:31]=[CH:32][CH:33]=2)[N:28]=[CH:27][N:26]=1)=[O:38]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66762340HCID 66762340, compound

Product 1

HCID 66763352HCID 66763352, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

59 mg (0.11 mmol) (3-{3-[(8-Carbamoyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-phenyl)-methyl-carbamic acid tert-butyl ester were dissolved in 3 ml dioxane and 560 μl 4 N HCl in dioxane were added. The mixture was stirred overnight, filtered and washed with dioxane.

Workup

  1. filtrationfiltered
  2. washwashed with dioxane

Sources & evidence

ORD record
ord-0936420f45724d009af666c9b70c0107
Source dataset
uspto-grants-2014_01
Patent number
US08637532B2

Reaction notes

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