反应详情

101 mg (0.37 mmol) N-(3-Aminomethyl-phenyl)-4-methoxy-N-methyl-benzamide were dissolved in 3 ml acetonitrile and 260 μl (1.87 mmol) triethylamine. 130 mg (0.37 mmol) 4-Chloro-quinazoline-8-carboxylic acid methyl ester were added and the mixture was stirred overnight. The solvent was removed, water was added and the mixture was extracted with ethyl acetate. The organic layer was dried over Na2SO4 and evaporated to dryness. The crude product was used in the next step without further purification.

1. customThe solvent was removed
2. additionwater was added
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialThe organic layer was dried over Na2SO4
5. customevaporated to dryness
6. customThe crude product was used in the next step without further purification