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HRID47449

反应详情

EQUATION

反应方程式

HRID 47449 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(N)cc1Cl
HCID21441

2-Chloro-4-anisidine

C7H8ClNO

结构：Cc1cc(NC(=O)C(Br)(Br)Br)c2c(F)ccc(F)c2n1
HCID22745136

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(NC(=O)Nc2cc(C)nc3c(F)ccc(F)c23)cc1Cl
HCID22745129

未命名化合物

收率 5.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Title compound (0.005 g) was prepared according to the method of Example 66 from acetamide D23 (0.118 g) and 3-chloro-4-methoxyaniline (0.039 g) but using pyridine as solvent. m/z (API+): 378 (MH+). 1H NMR δ: 2.62 (3H, s), 3.83 (1H, s), 7.13 (1H, d, J=9.0 Hz ), 7.28-7.40 (2H, m), 7.50-7.60 (1H, m), 7.74 (1H, d, J=2.6 Hz), 8.29 (1H, s), 8.86 (1H, d), 9.93 (1H, s).