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HRID 47449作成日：2026年10月25日

3-Chloro-4-methoxyaniline → 1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea

https://huagongshe.com/reaction/47449

反応式

関与物質

役割名称HCID仕込み量
反応物3-Chloro-4-methoxyanilineHCID 21441—
反応物2,2,2-Tribromo-N-(5,8-difluoro-2-methyl-quinolin-4-yl)-acetamideHCID 22745136—
溶媒PyridineHCID 1049—
生成物1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-ureaHCID 227451295.3%

反応手順

Title compound (0.005 g) was prepared according to the method of Example 66 from acetamide D23 (0.118 g) and 3-chloro-4-methoxyaniline (0.039 g) but using pyridine as solvent. m/z (API+): 378 (MH+). 1H NMR δ: 2.62 (3H, s), 3.83 (1H, s), 7.13 (1H, d, J=9.0 Hz ), 7.28-7.40 (2H, m), 7.50-7.60 (1H, m), 7.74 (1H, d, J=2.6 Hz), 8.29 (1H, s), 8.86 (1H, d), 9.93 (1H, s).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06699879B1
出典データセットuspto-grants-2004_03
ORD IDord-0f30a835c94a49a1a7eb4d5f1ff01618
出典メモuspto-grants-2004_03