HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474588Generated: October 26, 2026
Potassium Carbonate → 4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde
https://huagongshe.com/reaction/474588
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| Reactant | 3,4,5-Trifluorobenzaldehyde | HCID 2776954 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde | HCID 86666193 | 79.2% |
Reaction Steps
The mixture of 4-chloro-3-(trifluoromethyl)phenol (3.4 g, 17.30 mmol), 3,4,5-trifluorobenzaldehyde (2.7 g, 16.87 mmol) and K2CO3 (2.80 g, 20.24 mmol) in DMF was heated with a microwave reactor at 60° C. for 1 h. Purification via a flash column chromatography then afforded the title compound (4.5 g, 79% yield). LCMS: rt=3.88 min, [M+H+]=337
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-da3d57a365b14ac3adad97c1f06f9fd7 |
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| Source note | uspto-grants-2014_01 |
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