反应详情

To the solution of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-ethenylbenzonitrile (2.0 g, 6.18 mmol) in dry THF (14 mL), was added 9-BBN (18 mL, 9.00 mmol) at 0° C. The mixture was stirred at room temperature overnight. Water (1.113 mL, 61.8 mmol), aq. NaOH (12.36 mL, 37.1 mmol), and 30% H2O2 (3.16 mL, 30.9 mmol) were added then. The reaction mixture was heated at 55° C. for 4 h. Then THF was removed under reduced pressure, and the residue was diluted with EA. The organic layer was washed with water and brine, dried over anhydrous Na2SO4 and concentrated and purified by flash chromatography to afford the title compound (1.0 g, 2.93 mmol, 47.4% yield).

1. temperatureThe reaction mixture was heated at 55° C. for 4 h
2. customThen THF was removed under reduced pressure
3. additionthe residue was diluted with EA
4. washThe organic layer was washed with water and brine
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated
7. custompurified by flash chromatography