Potassium Carbonate → HCID 178518548, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-(Pyrimid-5-ylmethyl)-2-thiouracil	HCID 10966039	—
Reactant	4-Chloro-3-(trifluoromethyl)phenyl 4-(2-iodoethyl)phenyl ether	HCID 67775359	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 178518548	HCID 178518548	24.7%

Reaction Conditions

Temperature	60 °C

Reaction Steps

A mixture of 1-chloro-4-{[4-(2-iodoethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (50 mg, 0.117 mmol), K2CO3 (32.4 mg, 0.234 mmol), and 5-(5-pyrimidinylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (26 mg, 0.118 mmol) in DMF (1 mL) was heated with a microwave reactor at 60° C. for 0.5 h. Purification via MDAP then afforded the title compound (15 mg, 24.66% yield). LCMS: rt=3.62 min, [M+H+]=519

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637536B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-d2c64667bf084b5481471dedbc26ab25
Source note	uspto-grants-2014_01