Potassium Carbonate → HCID 178494136, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-{4-[(3-Chloro-4-methylphenyl)oxy]phenyl}ethyl imidocarbamate	HCID 67774878	—
Reactant	Methyl 2-formyl-3-(2-methoxypyrimidin-5-yl)propanoate	HCID 86666188	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	HCID 178494136	HCID 178494136	2.33%

Reaction Conditions

Temperature	130 °C

Reaction Steps

To the solution of 2-{4-[(3-chloro-4-methylphenyl)oxy]phenyl}ethyl imidocarbamate (150 mg, 0.359 mmol) and methyl 2-formyl-3-[2-(methyloxy)-5-pyrimidinyl]propanoate (89 mg, 0.395 mmol) in NMP (2 mL), was added K2CO3 (198 mg, 1.436 mmol). The mixture was heated with a microwave reactor at 130° C. for 1 h. Purification via MDAP then afforded the title compound (4 mg, 2.33% yield). LCMS: rt=3.54 min, [M+H+]=479

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08637536B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-191beb2761684c0bb751823cbe505e1c
Source note	uspto-grants-2014_01