HRID474963

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58093373

未命名化合物

结构：Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CCC2

HCID66874851

未命名化合物

PRODUCTS

生成物

结构：Cn1c2c(c3ccc(-n4ccc(OCc5ncc(Cl)cc5Cl)cc4=O)cc31)CN(C(=O)OC(C)(C)C)CCC2

HCID123288157

未命名化合物

收率 66.5%

PROCEDURE

实验过程

tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate (150 mg, 0.396 mmol) and 4-((3,5-dichloropyridin-2-yl)methoxy)pyridin-2(1H)-one (107 mg, 0.396 mmol) were reacted following the procedure for Example 2 (step d) to provide the title compound (150 mg, 66%) as a green oil: ESI MS m/z 569 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-34e65e4b34c8431dabffd055230112ff
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08637501B2
来源说明: uspto-grants-2014_01

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:13][CH2:12][C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1.[Cl:24][C:25]1[C:26]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][NH:37][C:36](=[O:40])[CH:35]=2)=[N:27][CH:28]=[C:29]([Cl:31])[CH:30]=1>>[Cl:24][C:25]1[C:26]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][N:37]([C:2]3[CH:3]=[CH:4][C:5]4[C:6]5[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:13][CH2:12][C:7]=5[N:8]([CH3:11])[C:9]=4[CH:10]=3)[C:36](=[O:40])[CH:35]=2)=[N:27][CH:28]=[C:29]([Cl:31])[CH:30]=1