HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((3,5-dichloropyridin-2-yl)methoxy)pyridin-2(1H)-one → tert-Butyl 8-(4-((3,5-dichloropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H) carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((3,5-dichloropyridin-2-yl)methoxy)pyridin-2(1H)-one | HCID 58093373 | — |
| Reactant | tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate | HCID 66874851 | — |
| Product | tert-Butyl 8-(4-((3,5-dichloropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H) carboxylate | HCID 123288157 | 66.5% |
Reaction Steps
tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate (150 mg, 0.396 mmol) and 4-((3,5-dichloropyridin-2-yl)methoxy)pyridin-2(1H)-one (107 mg, 0.396 mmol) were reacted following the procedure for Example 2 (step d) to provide the title compound (150 mg, 66%) as a green oil: ESI MS m/z 569 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637501B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-34e65e4b34c8431dabffd055230112ff |
| Source note | uspto-grants-2014_01 |