反应详情

2((2-Chloropyridin-4-yloxy)methyl)-3,5-difluoropyridine (3.42 g, 13.3 mmol) and ammonium acetate (20.5 g, 267 mmol) were heated at 110° C. in formic acid (45 mL) for 5 days. The mixture was concentrated to remove most of the liquid and then adjusted to pH 8 with NaHCO3 solution. The solid was filtered off to provide the title compound (2.02 g, 63%) as a white solid; ESI MS m/z 239 [M+H]+.

1. concentrationThe mixture was concentrated
2. customto remove most of the liquid
3. filtrationThe solid was filtered off