反应详情

To a stirred mixture of 33 (153 g, 804.25 mmol, 1.00 equiv) in EtOH (1 L) was added 1M aq. LiOH (1 L), and the resultant solution was stirred at reflux for 1 h. Volatile solvent was removed under reduced pressure and the residue diluted with EtOAc (1.5 L). The organic phase was washed with water (3×1 L) and brine (1×1 L), dried (Na2SO4), filtered and concentrated in vacuo to afford 117.5 g (90%) of trans-2-phenylcyclopropane-1-carboxylic acid (35) as a white solid.

1. temperatureat reflux for 1 h
2. customVolatile solvent was removed under reduced pressure
3. additionthe residue diluted with EtOAc (1.5 L)
4. washThe organic phase was washed with water (3×1 L) and brine (1×1 L)
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated in vacuo