HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile → (3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile | HCID 71272249 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia methanol | HCID 21705897 | — |
| Product | (3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine | HCID 71272763 | 91.5% |
Reaction Steps
To a solution of 3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile (130 mg, 0.54 mmol) in NH3/MeOH (7N, 10 mL) was added Raney nickel (20 mg). The mixture was stirred under hydrogen overnight. The reaction mixture was filtered, and the filtrate was concentrated to afford (3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine (120 mg, 91.5%). MS (ESI): m/z=246 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637537B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-f9d1859ead324f5d803e9bab1dd901d2 |
| Source note | uspto-grants-2014_01 |