Hydroxyamine hydrochloride → HCID 136336869, compound

HRID 475167Notes

Reaction equation

HRID 475167 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=O)[CH3:13])[CH:3]=1.Cl.[NH2:16][OH:17].CC([O-])=O.[Na+]>CCO>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=[N:16][OH:17])[CH3:13])[CH:3]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86694714HCID 86694714, compound

Product 1

HCID 136336869HCID 136336869, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

To the solution of 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone (900 mg, 4.68 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (1.64 g, 23.4 mmol, 5.0 eq.) and NaOAc (3.84 g, 46.8 mmol, 10 eq.). The mixture was stirred at 40° C. overnight, and the solvent was concentrated in vacuo to afford 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone oxime as a white solid (848 mg, 87%). MS (ESI): m/z=208.2 [M+1]+.

Workup

  1. concentrationthe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-b5c1a9679594480c94b066ae6c264968
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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