反应详情

温度

100 °C

To a solution of 38 (130 mg, 0.25 mmol) in MeOH (2 mL) was added a 2.0 N solution of KOH in water (2 mL). The mixture was stirred at 100° C. for 18 h. The solvent was evaporated under reduced pressure and the residue was purified by preparative HPLC to afford 20 mg (22%) of I-35 as white solid.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was purified by preparative HPLC
3. customto afford 20 mg (22%) of I-35 as white solid