HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475181Generated: October 26, 2026
Potassium Hydroxide → N2-((1H-Indol-6-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475181
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((1-tosyl-1H-indol-6-yl)methyl)pyrimidine-2,4-diamine | HCID 86694718 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | N2-((1H-Indol-6-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | HCID 86694719 | — |
Reaction Steps
To a solution of 38 (130 mg, 0.25 mmol) in MeOH (2 mL) was added a 2.0 N solution of KOH in water (2 mL). The mixture was stirred at 100° C. for 18 h. The solvent was evaporated under reduced pressure and the residue was purified by preparative HPLC to afford 20 mg (22%) of I-35 as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-7e67cd641614436c9ab335f0eedd38c7 |
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| Source note | uspto-grants-2014_01 |
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