反应详情

温度

100 °C

To a solution of 50 (330 mg, 0.73 mmol) in MeOH (5.0 mL) was added a solution of KOH (2.0 N, 5 mL). The mixture was heated in a sealed tube at 100° C. overnight then concentrated in vacuo. The residue was purified by preparative HPLC to afford 145 mg (57%) of I-38 as white solid.

1. concentrationthen concentrated in vacuo
2. customThe residue was purified by preparative HPLC
3. customto afford 145 mg (57%) of I-38 as white solid