HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475186Generated: October 27, 2026
Potassium Hydroxide → N2-((1H-Indol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475186
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((1-tosyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine | HCID 86694721 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N2-((1H-Indol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | HCID 71529250 | — |
Reaction Steps
To a solution of 50 (330 mg, 0.73 mmol) in MeOH (5.0 mL) was added a solution of KOH (2.0 N, 5 mL). The mixture was heated in a sealed tube at 100° C. overnight then concentrated in vacuo. The residue was purified by preparative HPLC to afford 145 mg (57%) of I-38 as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-0c280b1616fb4ba48871e09ac9c00b61 |
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| Source note | uspto-grants-2014_01 |
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