反应详情

To a solution of 124 (3 g, 8.58 mmol) in EtOAc (10 mL) was added HCl/EtOAc (25 mL, 2 M in EtOAc) dropwise and stirred at RT. When the reaction was complete the reaction mixture was filtered, the solid was collected and washed with EtOAc to afford 2 g (83%) of (1S)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)ethanamine hydrochloride (126) as a white solid.

1. filtrationwas filtered
2. customthe solid was collected
3. washwashed with EtOAc