(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methanamine → HCID 178461873, compound

HRID 475248Notes

Reaction equation

HRID 475248 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH:11][C:12]3[N:17]=[C:16]([NH:18][C:19]4[CH:23]=[C:22]([C@@H:24]5[CH2:26][C@H:25]5[C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)[NH:21][N:20]=4)[CH:15]=[CH:14][N:13]=3)=[CH:9][C:4]=2[N:3]=[CH:2]1.O1CCCC[CH:34]1N1C2C=CC(CN)=CC=2N=C1>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@@H:10]([NH:11][C:12]3[N:17]=[C:16]([NH:18][C:19]4[CH:23]=[C:22]([C@@H:24]5[CH2:26][C@H:25]5[C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)[NH:21][N:20]=4)[CH:15]=[CH:14][N:13]=3)[CH3:34])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 46739877(1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methanamineHCID 178420295HCID 178420295, compound

Product 1

HCID 178461873HCID 178461873, compound

Procedure

N2-(1H-Benzimidazol-5-ylmethyl)-N4-[5-[(trans)-2-phenylcyclopropyl]-1H-pyrazol-3-yl]pyrimidine-2,4-diamine (I-27) prepared analogously starting from 91 and condensing with (1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methanamine (28) and subsequently removing the pyran in accord with the procedure in steps 6 and 7 of example 1.

Workup

  1. customsubsequently removing the pyran in accord with the procedure in steps 6 and 7 of example 1

Sources & evidence

ORD record
ord-0420996c9c45422ab5d32a4566c3e557
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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