HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475269Generated: October 30, 2026
Diisopropylethylamine → N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-methyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475269
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3-methyl-1H-indol-4-yl)methanamine | HCID 83815702 | — |
| Reactant | HCID 178478345 | HCID 178478345 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-methyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine | HCID 86694747 | — |
Reaction Steps
A tube was charged with 53 (200 mg, 0.85 mmol), 234 (181 mg, 1.13 mmol), DIPEA (0.2 mL) and IPA (2 mL), degassed, sealed and heated at 120° C. overnight. The solvent was concentrated to dryness in vacuo. The residue was purified by preparative HPLC to afford 80 mg (26%) of I-92 as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-478e5b2bf3114494b37dbee024885d9e |
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| Source note | uspto-grants-2014_01 |
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