反应详情

温度

120 °C

A tube was charged with 53 (200 mg, 0.85 mmol), 234 (181 mg, 1.13 mmol), DIPEA (0.2 mL) and IPA (2 mL), degassed, sealed and heated at 120° C. overnight. The solvent was concentrated to dryness in vacuo. The residue was purified by preparative HPLC to afford 80 mg (26%) of I-92 as white solid.

1. customdegassed
2. customsealed
3. concentrationThe solvent was concentrated to dryness in vacuo
4. customThe residue was purified by preparative HPLC
5. customto afford 80 mg (26%) of I-92 as white solid