HCID 71529203, compound → HCID 86694755, compound

HRID 475289Notes

Reaction equation

HRID 475289 reaction equation
N1C2C(=C(C[NH:11][C:12]3[N:17]=[C:16]([NH:18][C:19]4[CH:23]=[C:22]([CH:24]5[CH2:28][CH2:27]CO5)[NH:21][N:20]=4)[CH:15]=[CH:14][N:13]=3)C=CC=2)C=C1.ClC1N=C(NC2C=C([C@@H]3C[C@H]3C3C=CC=CC=3[F:51])NN=2)C=CN=1>>[CH:24]1([C:22]2[NH:21][N:20]=[C:19]([NH:18][C:16]3[C:15]([F:51])=[CH:14][N:13]=[C:12]([NH2:11])[N:17]=3)[CH:23]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 71529203HCID 71529203, compoundHCID 86694756HCID 86694756, compound

Product 1

HCID 86694755HCID 86694755, compound

Procedure

N2-((1H-indol-4-yl)methyl)-N4-(5-(tetrahydrofuran-2-yl)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (I-119) and N2-(1H-indol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoropyrimidine-2,4-diamine (I-120) were prepared analogously except 2-chloro-N-(5-(trans-2-(2-fluorophenyl)cyclopropyl)-1H-pyrazol-3-yl)pyrimidin-4-amine was replaced with 83 and 55, respectively

Sources & evidence

ORD record
ord-7376b6b2475546d9a31ab07c89483a78
Source dataset
uspto-grants-2014_01
Patent number
US08637537B2

Reaction notes

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