HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475292Generated: October 26, 2026
Diisopropylethylamine → N2-((1H-Indol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-methylpyrimidine-2,4-diamine
https://huagongshe.com/reaction/475292
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | [(1H-indol-4-yl)methyl](methyl)amine | HCID 12513770 | — |
| Reactant | HCID 178478345 | HCID 178478345 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N2-((1H-Indol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-methylpyrimidine-2,4-diamine | HCID 71529458 | — |
Reaction Steps
A tube was charged with 116 (280 mg, 1.75 mmol), 53 (412 mg, 1.75 mmol), DIPEA (678 mg, 5.25 mmol) and IPA (5 mL), sealed and heated at 120° C. for 14 h. The mixture was concentrated in vacuo and the residue was purified by preparative HPLC to afford 260 mg (41.4%) of I-40.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08637537B2 |
|---|
| Source dataset | uspto-grants-2014_01 |
|---|
| ORD ID | ord-7b0d12c3aaff4c66972a37c7c2206638 |
|---|
| Source note | uspto-grants-2014_01 |
|---|
