反应详情

温度

120 °C

A tube was charged with 116 (280 mg, 1.75 mmol), 53 (412 mg, 1.75 mmol), DIPEA (678 mg, 5.25 mmol) and IPA (5 mL), sealed and heated at 120° C. for 14 h. The mixture was concentrated in vacuo and the residue was purified by preparative HPLC to afford 260 mg (41.4%) of I-40.

1. customsealed
2. concentrationThe mixture was concentrated in vacuo
3. customthe residue was purified by preparative HPLC
4. customto afford 260 mg (41.4%) of I-40