HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475295Generated: October 26, 2026
Diisopropylethylamine → N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((1-methyl-1H-indol-5-yl)methyl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475295
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1-methyl-1H-indol-5-yl)methylamine | HCID 18525752 | — |
| Reactant | 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 58169118 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((1-methyl-1H-indol-5-yl)methyl)pyrimidine-2,4-diamine | HCID 71272215 | — |
Reaction Steps
A microwave vial was charged with 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine (160 mg, 0.68 mmol), 296 (800 mg, 5.59 mmol), DIPEA (1 ml), and IPA (5.0 mL), sealed and heated at 120° C. for 18 h. It was concentrated and purified by SiO2 chromatography, and then preparative HPLC to afford 30 mg (12%) of I-33 as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-f0bb7d6be6034ea0984653c6e25a8990 |
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| Source note | uspto-grants-2014_01 |
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