6-amino-3-bromo-2-fluorobenzonitrile → 6-Bromo-2-chloro-5-fluoroquinazoline

HRID 475321Notes

Reaction equation

HRID 475321 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10](OC)[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2.NC1C=CC(Br)=C([F:25])C=1C#N>>[Br:1][C:2]1[C:3]([F:25])=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2

Participants

3

Reactant 2

HCID 27611996-amino-3-bromo-2-fluorobenzonitrileHCID 467382966-Bromo-2-chloro-8-methoxyquinazoline

Product 1

HCID 574611366-Bromo-2-chloro-5-fluoroquinazoline

Procedure

6-bromo-2-chloro-5-fluoro-quinazoline is prepared analogously to WO 2007/117607 or to the above-mentioned synthesis of 6-bromo-2-chloro-8-methoxy-quinazoline starting from 2-amino-5-bromo-6-fluoro-benzonitrile.

Sources & evidence

ORD record
ord-29843d3dc15349dc9dfb4e5790aa0626
Source dataset
uspto-grants-2014_01
Patent number
US08637549B2

Reaction notes

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