反应详情

温度

45 °C

To a stirred suspension of 2-(6-bromobenzo[d]isoxazol-3-yl)benzaldehyde (Compound 4a) (10 g) in dry ethanol (100 mL) was added p-toluenesulfonic acid (0.315 g) followed by triethyl orthoformate (11.01 mL, 9.81 g). The suspension was stirred at 45° C. until a clear solution resulted and then maintained at 45° C. for 45 min. The solvent was removed under vacuum and then the mixture was diluted with ethyl acetate and then washed with saturated sodium carbonate solution, brine and then dried over anhydrous sodium sulfate, filtered and evaporated to give the title product (12.6 g).

1. customresulted
2. temperaturemaintained at 45° C. for 45 min
3. customThe solvent was removed under vacuum
4. additionthe mixture was diluted with ethyl acetate
5. washwashed with saturated sodium carbonate solution, brine
6. dry with materialdried over anhydrous sodium sulfate
7. filtrationfiltered
8. customevaporated