Sulfuric acid magnesium salt (1:1) → HCID 178505794, compound

HRID 475431Notes

Reaction equation

HRID 475431 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[CH:11]=O)=[N:7][O:8][C:4]=2[CH:3]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[NH2:27])=[CH:22][CH:21]=1.S([O-])([O-])(=O)=O.[Mg+2]>ClCCl>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3/[CH:11]=[N:27]/[CH:26]([C:23]3[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=3)[C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 109550394-Fluoro-alpha-(4-fluorophenyl)benzenemethanamineHCID 866759952-(6-Bromobenzo[d]isoxazol-3-yl)benzaldehyde2×

Product 1

HCID 178505794HCID 178505794, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 2-(6-bromobenzo[d]isoxazol-3-yl)benzaldehyde (compound 7) (2 g) in dichloromethane (33 mL) was added bis(4-fluorophenyl)methanamine (1.74 g) and anhydrous magnesium sulfate and stirred under nitrogen at room temperature for 18 h. Filtration and evaporation of the filtrate and crystallisation from dichloromethane-methanol gave the title compound (2.4 g).

Workup

  1. filtrationFiltration and evaporation of the filtrate and crystallisation from dichloromethane-methanol

Sources & evidence

ORD record
ord-4015796ac46d441698388cef6c323ce6
Source dataset
uspto-grants-2014_01
Patent number
US08637551B2

Reaction notes

Loading…