Ammonium Hydroxide → HCID 58713637, compound

HRID 475506Notes

Reaction equation

HRID 475506 reaction equation
O=C1CCC(=O)N1[O:8][C:9]([C:11]1[C:15]2[CH2:16][C:17](=[O:19])[CH2:18][C:14]=2[N:13]([CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:12]=1)=O.[NH4+:27].[OH-]>O1CCOCC1>[CH2:20]([N:13]1[C:14]2[CH2:18][C:17](=[O:19])[CH2:16][C:15]=2[C:11]([C:9]([NH2:27])=[O:8])=[N:12]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 58713650HCID 58713650, compound

Product 1

HCID 58713637HCID 58713637, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of the intermediate from step D (2.0 g, 5.25 mmol) in 1,4-dioxane (50 mL) was added NH4OH (14.8 N, 10.0 eq, 3.53 mL). A precipitate formed immediately. After stirring at room temperature for 15 minutes the reaction mixture was filtered through a fritted funnel and the precipitate washed with 1,4-dioxane. The filtrate was concentrated in vacuo to give a solid.

Workup

  1. customA precipitate formed immediately
  2. filtrationwas filtered through a fritted funnel
  3. washthe precipitate washed with 1,4-dioxane
  4. concentrationThe filtrate was concentrated in vacuo
  5. customto give a solid

Sources & evidence

ORD record
ord-cfce435e53e940fd89e04e91eff2ae43
Source dataset
uspto-grants-2014_01
Patent number
US08637555B2

Reaction notes

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