Hydrochloric Acid → HCID 86658988, compound

HRID 475524Notes

Reaction equation

HRID 475524 reaction equation
CO.[OH-].[K+].Cl.C[O:7][C:8]([CH:10]1[CH2:15][CH2:14][CH:13]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH:24]=[C:25]3[S:29][C:28](=[O:30])[NH:27][C:26]3=[O:31])=[CH:20][CH:19]=2)[CH2:12][CH2:11]1)=[O:9]>O>[O:30]=[C:28]1[NH:27][C:26](=[O:31])/[C:25](=[CH:24]/[C:21]2[CH:22]=[CH:23][C:18]([O:17][CH2:16][CH:13]3[CH2:12][CH2:11][CH:10]([C:8]([OH:9])=[O:7])[CH2:15][CH2:14]3)=[CH:19][CH:20]=2)/[S:29]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 75180750HCID 75180750, compound

Product 1

HCID 86658988HCID 86658988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 30 ml of methanol in which methyl-4-((4-((2,4-dioxothiazolidine-5-ylidene)methyl)phenoxy)methyl)cyclohexane carboxylate prepared in Example 66 was dissolved, 2N KOH (30 ml) was added while stirring. The mixture was stirred for 1 hour under reflux, then diluted with water and acidified by HCl. Subsequently, the precipitate thus formed was washed with water and dried to afford 4-({4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}methyl)cyclohexane carboxylic acid (Derivative 111 having the above formula) as white solid (0.74 g, yield: 77.1%).

Workup

  1. stirringThe mixture was stirred for 1 hour
  2. temperatureunder reflux
  3. customSubsequently, the precipitate thus formed
  4. washwas washed with water
  5. customdried

Sources & evidence

ORD record
ord-0279f27f482046e49bdd62d49ea2439f
Source dataset
uspto-grants-2014_01
Patent number
US08637558B2

Reaction notes

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