1,3-Dichloroacetone → 4-Chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazole

HRID 475555Notes

Reaction equation

HRID 475555 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([NH2:9])=[O:8])[CH3:2].[Cl:15][CH2:16][C:17](=O)[CH2:18]Cl>>[Cl:15][CH2:16][C:17]1[N:9]=[C:7]([C:6]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=2)[O:8][CH:18]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 50051063-Ethoxy-4-methoxybenzamide

Product 1

HCID 689842544-Chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazoleYield 49.4%

Procedure

Using 29.4 g of 3-ethoxy-4-methoxybenzamide and 57 g of 1,3-dichloro-2-propanone and following the procedure of Reference Example 55, 19.9 g of white powdery 4-chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazole was obtained.

Sources & evidence

ORD record
ord-e6f3fbb8cfa54f2e98b0954f94ad5bf3
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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