Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475555Generated: October 30, 2026

1,3-Dichloroacetone → 4-Chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazole

https://huagongshe.com/reaction/475555

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
Reactant3-Ethoxy-4-methoxybenzamideHCID 5005106—
Product4-Chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazoleHCID 6898425449.4%

Reaction Steps

Using 29.4 g of 3-ethoxy-4-methoxybenzamide and 57 g of 1,3-dichloro-2-propanone and following the procedure of Reference Example 55, 19.9 g of white powdery 4-chloromethyl-2-(3-ethoxy-4-methoxyphenyl)oxazole was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08637559B2
Source datasetuspto-grants-2014_01
ORD IDord-e6f3fbb8cfa54f2e98b0954f94ad5bf3
Source noteuspto-grants-2014_01