Homoallyl bromide → HCID 86633760, compound

HRID 475607Notes

Reaction equation

[F:1][CH:2]([F:29])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:28])[CH2:12][CH2:13][C:14]1[N:15]=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([OH:27])[CH:20]=2)[O:17][CH:18]=1.Br[CH2:31][CH2:32][CH:33]=[CH2:34]>>[CH2:34]([O:27][C:21]1[CH:20]=[C:19]([C:16]2[O:17][CH:18]=[C:14]([CH2:13][CH2:12][C:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][CH2:3][CH:2]([F:1])[F:29])=[O:28])[N:15]=2)[CH:24]=[CH:23][C:22]=1[O:25][CH3:26])[CH2:33][CH:32]=[CH2:31]

Participants

Reactant 2

HCID 21241Homoallyl bromide

HCID 86633758HCID 86633758, compound

Product 1

HCID 86633760HCID 86633760, compound

Procedure

Using the compound obtained in Example 272 and 4-bromo-1-butene, white powdery 3-[2-(3-but-3-enyloxy-4-methoxyphenyl)oxazol-4-yl]-1-[2-(2,2-difluoroethoxy)phenyl]propan-1-one was obtained following the procedure of Example 3.

Sources & evidence

ORD record: ord-3c67c63b7c4f415682f87676cf6e5ac0
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08637559B2

Reaction notes

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