2-Bromopropane → HCID 86633761, compound

HRID 475614Notes

Reaction equation

[F:1][CH:2]([F:28])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:12]2[O:13][CH:14]=[C:15]([CH2:17][CH2:18][C:19]([C:21]3[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][N:22]=3)=[O:20])[N:16]=2)[CH:8]=[CH:9][C:10]=1[OH:11].Br[CH:30]([CH3:32])[CH3:31]>>[F:28][CH:2]([F:1])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:12]2[O:13][CH:14]=[C:15]([CH2:17][CH2:18][C:19]([C:21]3[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][N:22]=3)=[O:20])[N:16]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:30]([CH3:32])[CH3:31]

Participants

Reactant 2

HCID 63582-Bromopropane

HCID 136356811HCID 136356811, compound

Product 1

HCID 86633761HCID 86633761, compound

Procedure

Using the compound obtained in Example 317 and 2-bromopropane, white powdery 3-{2-[3-(2,2-difluoroethoxy)-4-isopropoxyphenyl]oxazol-4-yl}-1-(3-methylpyridin-2-yl)propan-1-one was obtained following the procedure of Example 3.

Sources & evidence

ORD record: ord-423f06beb0544902b064d5618ae3a7e7
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08637559B2

Reaction notes

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